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Laboratory of Lipid Dynamics & Ion Channel Research

Professor

Professor

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    Byung-Chang SuhProfessor

    • 연구실Room #309, Brain Science Building (E4)
    • 최종학력Postdoctoral Fellow, in lieu of 3-year military service requirement Basic Science Research Center, POTECH, Pohang, Korea
    • 주요연구분야 Seven transmembrane receptor-mediated modulation of voltage-gated ion channels is critical for physiological control of excitable cells including neurons and myocytes
    • Tel.053-785-6123
    • E-mail.bcsuh@dgist.ac.kr
    • Office.Room #309, Brain Science Building (E4)

Education

  • 1991 B.S. Seoul National University, Department of Agricultural Biology, Seoul, Korea
  • 1994 M.S. POSTECH, Department of Life Science, Neurophysiology, Pohang, Korea
  • 1997 Ph.D. POSTECH, Department of Life Science, Molecular Neurophysiology, Pohang, Korea

Research Experience

  • 1997-2001 Postdoctoral Fellow, in lieu of 3-year military service requirement Basic Science Research Center, POTECH, Pohang, Korea
  • 2001-2004 Senior Fellow, Department of Physiology and Biophysics University of Washington, Seattle, USA
  • 2004-2010 Research Assistant Professor, Department of Physiology and Biophysics University of Washington, Seattle, USA
  • 2011-2015 Assistant Professor, Department of Brain & Cognitive Sciences Daegu Gyeongbuk Institute of Science & Techonology (DGIST), Daegu, Korea
  • 2015- Associate Professor, Department of Brain & Cognitive Sciences Daegu Gyeongbuk Institute of Science & Techonology (DGIST), Daegu, Korea

Honors, Awards, Experience, and Other Professional Activities

2011-2012 KBRI Research Planning Team
2010- Marquis Who’s Who in the World
2006-2010 Advisor and Principal, Korean-Language School of Everett WA in Northwest America
2008 University of Washington Provost Workshop on Teaching
2007 University of Washington Conference on Teaching and Learning for Teachers
2007 University of Washington Future Faculty Workshop
2005-2006 Advanced English presentation, pronunciation, and writing
2003- Member, Society for Neuroscience
1994 The Young Scientist Award from the Korean Research Foundation

Areas of Research Interest

Seven transmembrane receptor-mediated modulation of voltage-gated ion channels is critical for physiological control of excitable cells including neurons and myocytes. My research interest is to understand the signaling mechanisms that couple heterotrimeric G protein-coupled receptors (GPCRs) to modulation of voltage-gated ion channels in neuronal systems. I will test the hypotheses that membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) acts as the generalized diffusible messenger in the slow modulation of voltage-activated ion (K+ and Ca2+) channels in mammalian cells. I will use two novel exogenous PIP2 5-phosphatase systems that modify the phosphoinositides within seconds in living cells without receptor activation, in combination with electrophysiology, confocal imaging, and fluorescence resonance energy transfer (FRET) techniques. The molecular mechanisms underlying this PIP2 turnover and its modulation of voltage-gated ion channels is critical to understanding the pathophysiological relevance of phosphoinositides in the channel-mediated regulation of cell excitability.

Invited Presentations (Selected)

  1. Gordon Research Conference "Ion Channels" July 2002, Tilton, NH Lecture title, "Muscarinic modulation and recovery of M-current may be breakdown and resynthesis of PIP2"
  2. Brown University, Pharmacology, Physiology & Biotechnology, Feb, 2007, Providence, RI “Phosphoinositide regulation of voltage-gated K+ channels”
  3. Duke University Medical School, Department of Pharmacology and Cancer Biology, July 20, 2007, Durham, NC “Modulation of KCNQ K+ channels by PIP2”
  4. Inositide Signaling Symposium Janelia Farm, Ashburn, VA. Nov. 4-7, 2007 “Regulation of voltage-sensitive Ca2+ channels by phosphatidylinositol 4,5-bisphosphate”
  5. University of Michigan Medical School, Department of Pharmacology, April, 2008, Ann Arbor, MI “Modulation of ion channels by membrane phosphoinositides”

Techniques that I have applied to my Research

  1. Electrophysiology: studying the modulation of ion channels using patch clamp techniques.
  2. Confocal microscopy: measuring the turnover of phosphoinositide lipids and translocation of cytosolic proteins using confocal microscopy.
  3. Photometry: measuring cytosolic Ca2+, Mg2+, Na+, pH using fluorescent dyes.
  4. Fluorescence resonance energy transfer (FRET): detection of lipid metabolism and protein coupling using two different fluorescent probes.
  5. Molecular biology: general molecular techniques for generating DNA constructs.
  6. Biochemistry: measuring cytosolic second messengers like IP3, cAMP, superoxide, etc.
  7. Animal cell culture: culturing primary cells and cell lines, and expressing exogenous cDNAs by diverse transfection methods.